Pharmacokinetics

DOSAGE AND ADMINISTRATION In the male:

· Hypogonadotrophic hypogonadism: 375-1000 IU 2-3 times per week;

· Delayed puberty associated with insufficient gonadotrophic pituitary function: 1500 IU twice weekly for at least 6 months.

· Cryptorchism, not due to an anatomic obstruction; Under 6 years of age: 500 IU twice weekly for 6 weeks. Over 6 years of age: 1000 IU twice weekly for 6 weeks. If necessary, this treatment can be repeated.

· Sterility in selected cases of deficient spermatogenesis:
Usually, 3000 IU per week in combination with a FSH containing preparation.

In the female:

Sterility due to the absence of follicle-ripening or ovulation: usually, 5000-10000 IU to complete treatment with a FSH containing preparation. A repeat injection of 5000 IU may be given 7 days later (or in accordance with individual patient needs) to prevent insufficiency of the corpus luteum.