Adverse Effects
Immune system disorders
In rare cases generalised rash or fever may occur.
General disorders and administrative site conditions
hCG may cause reactions at the site of injection, such as bruising, pain, redness, swelling and itching. Occasionally allergic reactions have been reported, mostly manifesting as pain and/or rash at the injection site.
In the female:
Vascular disorders
In rare instances, thromboembolism has been associated with FSH/hCG therapy, usually associated with severe OHSS.
Respiratory, thoracic and mediastinal disorders Hydrothorax, as a complication of severe OHSS.
Gastrointestinal disorders
Abdominal pain and gastrointestinal symptoms such as nausea and diarrhoea, related to mild OHSS. Ascites, as a complication of severe OHSS.
Reproductive system and breast disorders
Unwanted ovarian hyperstimulation, mild or severe ovarian hyper stimulation syndrome (OGSS).
Painful breasts, mild to moderate enlargement of ovaries and ovarian cysts related to mild OHSS. Large ovarian cysts (prone to rupture), usually associated with severe OHSS.
Investigations
Weight gain as a characteristic of severe OHSS.
In the male:
Metabolism and nutrition disorders
Water and sodium retention is occasionally seen after administration of high dosages; this is regarded as a result of excessive androgen production.
Reproductive system and breast disorders
hCG treatment may sporadically cause gynaecomastia.
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